Lactate: a major and crucial player in normal function of both muscle and brain.

摘要

Although lactate has been known for almost 80 years to serve as an oxidative energy-source in the brain (Ashford & Holmes, 1931), the work of Hill et at. (1924). on skeletal muscle, characterizing the mono-carboxylate as a useless by-product of anaerobic exercise, has been, in large part, responsible for lactate's bad reputation both in health and disease. It would not be too far-fetched to presume that the formulators of the glycolytic pathway seven decades ago took into account lactate's reputation in deciding that pyruvate is the end-product of aerobic glycolysis (Schurr, 2006)