Reducing high blood pressure (BP) improves cardiovascular mortality and morbidity. It has been estimated that about 14% of all deaths worldwide are directly attributable to elevated BP, so its effective monitoring and lowering in patients with hypertension is fundamental. Nevertheless, over the past 2 decades, several reports have suggested that excessive BP lowering may increase morbidity and mortality, especially in patients with coronary artery disease (CAD) and when diastolic BP falls below 80 to 85 mm Hg. This so-called J-curve relation has been debated ever since, and its relevance was recently acknowledged by the European Society of Hypertension in its reappraisal of the European guidelines on hypertension management.
展开▼
机译：降低血压（BP）可提高心血管疾病的死亡率和发病率。据估计，全世界所有死亡中约有14％直接归因于BP升高，因此对高血压患者进行有效监测和降低血压至关重要。然而，在过去的20年中，一些报告表明，血压过度降低可能会增加发病率和死亡率，特别是在患有冠状动脉疾病（CAD）的患者以及舒张压低于80至85 mm Hg的患者中。此后一直在讨论这种所谓的J曲线关系，最近，欧洲高血压学会在重新评估欧洲高血压管理指南时也承认了这种关系。
展开▼
