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The mechanobiological effects of periosteal surface loads

机译:骨膜表面负荷的力学生物学效应

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We have developed an improved mechanobiological model of bone morphogenesis and functional adaptation that includes the influences of periosteum tension and pressure on bone formation and resorption. Previous models assumed that periosteal and endosteal bone deposition and resorption rates are governed only by the local intracortical daily stress or strain stimulus caused by cyclic loading. The new model incorporates experimental findings that pressures on periosteal surfaces can impede bone formation or induce bone resorption, whereas periosteal tensile strains perpendicular to bone surfaces can impede bone resorption or induce bone formation. We propose that these effects can produce flattened or concave bone surfaces in regions of periosteal pressure and bone ridges in regions of periosteal tension. The model was implemented with computer simulations to illustrate the role of adjacent muscles on the development of the triangular cross-sectional geometry of the rat tibia. The results suggest that intracortical stresses dictate bone size, whereas periosteal pressures may work in combination with intracortical stresses and other mechanobiological factors in the development of local bone cross-sectional shapes.
机译:我们已经开发了一种改进的骨形态发生和功能适应性的力学生物学模型,其中包括骨膜张力和压力对骨形成和吸收的影响。以前的模型假定骨膜和骨内膜的骨沉积和吸收速率仅受循环负荷引起的局部皮质内每日压力或应变刺激支配。新模型结合了实验发现,即骨膜表面的压力会阻碍骨形成或引起骨吸收,而垂直于骨表面的骨膜拉伸应变会阻碍骨吸收或引起骨形成。我们建议这些效果可以在骨膜压力区域产生平坦或凹入的骨表面,在骨膜张力区域产生骨脊。该模型通过计算机模拟实现,以说明相邻肌肉在大鼠胫骨三角形横截面几何形状发展中的作用。结果表明,皮质内应力决定了骨的大小,而骨膜内压力可能与皮质内应力和其他机械生物学因素共同作用,形成了局部骨横截面形状。

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