Idiopathic pulmonary fibrosis is a complex genetic disease; mutations in surfactant protein C, telomerase, and surfactant protein A2 have been identified in familial cases of pulmonary fibrosis. We confirm a recent association with rs35705950 in the putative promoter of MUC5B and sporadic idiopathic pulmonary fibrosis. Patients with idiopathic pulmonary fibrosis were recruited independently from the Simmons Center for Interstitial Lung Diseases at the University of Pittsburgh Medical Center between 2003 and 2010 and from the Interstitial Lung Disease Center at the University of Chicago between 2006 and 2009. Our study was approved by the institutional review boards of both universities, and patients provided written informed consent for participation.
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