Palladium-Catalyzed Regio- and Stereoselective Formate Reduction of Fluorine-Containing Allylic Mesylates.A New Entry for the Construction of a Tertiary Carbon Attached with a Fluoroalkyl Group

摘要

The regioselective palladium-catalyzed formate reduction of gamma-fluoroalkylated allylic esters is described.Reduction of the allylic esters under the influence of palladium with a monodentate phosphine ligand proceeded preferentially at the gamma position,the corresponding reduction products with a fluoroalkyl group at the tertiary carbon being afforded in high yields.When the chiral allylic ester was employed,complete chirality transfer was observed,leading to the optically active materials in high yields.