A New Convenient Synthesis of Propargylic Fluorohydrins and 2,5-Disubstituted Furans from Fluoropropargyl Chloride

摘要

Fluoropropargyl chloride reacted with carbonyl compounds to give propargylic fluorohydrins under mild conditions and in good yields;however,at higher temperatures and longer reaction times,2,5-disubstituted furans are obtained,also in good yields.Fluorohydrins can be readily oxidized to alpha-fluoroketones and alpha-fluorocarboxylic acids with Jones' reagent.