EREMOPHILANE-TYPE SESQUITERPENES FROM Alpinia oxyphylla WITH INHIBITORY ACTIVITY AGAINST NITRIC OXIDE PRODUCTION

摘要

Phytochemical investigation of the fruits of Alpinia oxyphylla led to the isolation of 12 eremophilane sesquiterpenes, including a novel noreremophilane sesquiterpene, (4R*,5R*)-7-acetyl-4,5-dimethyl-4,5,8,9- tetrahydronaphthalen-2(3H)-one (oxyphyllanone A, 1), along with eleven known compounds (2–12). Among them, compounds 2–6, 9, and 11 were isolated from this genus for the first time. Their structures were determined on the basis of spectroscopic analysis, including 2D NMR spectroscopic techniques. The tested compounds 2–12 showed different inhibitory activity against NO production in interferon-γ- and lipopolysaccharide-induced RAW264.7 macrophage cells, and compound 11 was the most active one with IC50 value of 4.61 μg/mL.