5% hypertonic saline with epinephrine is safe and may be effective in the treatment of bronchiolitis.

摘要

Question Among infants with acute bronchiolitis in an urgent care setting, does the use of nebulized saline solution improve respiratory symptoms? Design Double-blind, randomized trial. Setting Urban urgent care setting in Qatar. Participants 171 infants aged <18 months (mean age, 3.1 months) clinically diagnosed with bronchiolitis. Intervention Infants were randomized to receive nebulized 5%, 3%, or 0.9% (normal) saline with epinephrine every 4 hours. Outcomes The primary efficacy outcome was improved bronchiolitis severity score at 48 hours. Safety was assessed by monitoring severity score and oxygen saturation with each treatment.