Relationship between germline MC1R variants and BRAF-mutant melanoma in a North Carolina population-based study.

摘要

A few previous studies have examined the relationship between germline mela-nocortin-1 receptor (MC1R) status and somatic BRAF mutations in melanoma. Two publications reported strong associations in three independent populations (two from Italy and one from San Francisco) (Landi et al., 2006; Fargnoli et al., 2008), whereas a more recent publication found no association in an Australian population-based study (Hacker et al., 2010). We report our finding of no significant association between MC1R status and BRAF-mutant melanomas in a population-based study of malignant melanoma in North Carolina.