Synthesis of Betulin 28-(2-Bromoacetate) Conjugates with Uracil and its Methyl-Substituted Homologs

Dubovitskii S. N.; Komissarova N. G.; Shitikova O. V.; Spirikhin L. V.; Abdullin M. F.; Yunusov M. S.

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Synthesis of Betulin 28-(2-Bromoacetate) Conjugates with Uracil and its Methyl-Substituted Homologs

机译：Betulin 28-（2-Bromoacetate）的合成与尿嘧啶及其甲基取代的同系物

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摘要

A series of potentially biologically active betulin derivatives containing various C-28 2-uracilacetoxy substituents were synthesized.

机译：合成了一系列含有各种C-28 2-尿嘧啶乙酰氧基取代基的潜在生物活性的桦木素衍生物。

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来源
《Chemistry of Natural Compounds》 |2015年第3期|共7页
作者
Dubovitskii S. N.; Komissarova N. G.; Shitikova O. V.; Spirikhin L. V.; Abdullin M. F.; Yunusov M. S.;
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正文语种 eng
中图分类化学;
关键词
betulin; betulin 28-(2-bromoacetate); uracil; 5-methyluracil; 6-methyluracil; 3; 6-dimethyluracil;

机译：桦木酚;betulin 28-（2-溴乙酸盐）;尿嘧啶;5-甲基尿嘧啶;6-甲基尿嘧啶;3;6-二甲基尿嘧啶;

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专利

1. Synthesis of Betulin 28-(2-Bromoacetate) Conjugates with Uracil and its Methyl-Substituted Homologs [J] . Dubovitskii S. N., Komissarova N. G., Shitikova O. V., Chemistry of Natural Compounds . 2015,第3期

机译：Betulin 28-（2-Bromoacetate）的合成与尿嘧啶及其甲基取代的同系物
2. 1H-1,2,3-triazole-tethered uracil-ferrocene and uracil-ferrocenylchalcone conjugates: Synthesis and antitubercular evaluation [J] . Singh Amandeep, Biot Christophe, Viljoen Albertus, Chemical biology and drug design . 2017,第6期

机译：1H-1,2,3-三唑 - 系骨尿嘧啶 - 二茂铁和尿嘧啶 - 铁核基凝聚酮：合成和抗胆管评估
3. Sugar migration induced by the Wagner-Meerwein rearrangement of 28-O-glycosyl-betulin derivatives [J] . Anna Korda, Zbigniew Pakulski, Piotr Cmoch, Tetrahedron . 2017,第13期

机译：由瓦格纳-Meerwein诱导的糖迁移为28- o - 糖基 - 桦木蛋白衍生物
4. Studying on Extraction of Betulin from the White Birch and Synthesis of Betulinic Acid [C] . Tong-Cun Zhang, Weiwei Xu, Nan Wang, International conference on applied biotechnology . 2014

机译：白桦提取桦木素及合成桦木酸的研究
5. I:- Design, synthesis and study of nucleotide prodrugs. II:- Synthesis of 5-fluoro-6-[(2-aminoimidazol-1-yl)methyl]uracil (AIFU) and study of its mechanism of action as a thymidine phosphorylase inhibitor. III:- Design and synthesis of novel nucleotide analogs as alternative substrates for studying the mechanism of the thymidylate synthase-catalyzed reaction. [D] . Jain, Harsh Vardhan. 2010

机译：I：-核苷酸前药的设计，合成和研究。 II：5-氟-6-[（（2-氨基咪唑-1-基）甲基]尿嘧啶（AIFU）的合成及其作为胸苷磷酸化酶抑制剂的作用机理的研究。 III：-设计和合成新型核苷酸类似物作为研究底物胸苷酸合酶催化反应机理的替代底物。
6. Design synthesis and anti-HIV-1 activity of 1-aromatic methyl-substituted 3-(35-dimethylbenzyl)uracil and N-35-dimethylbenzyl-substituted urea derivatives [O] . Norikazu Sakakibara, Masanori Baba, Mika Okamoto, 2015

机译：1-芳族甲基取代的3-（35-二甲基苄基）尿嘧啶和N-35-二甲基苄基取代的尿素衍生物的设计合成和抗HIV-1活性
7. Isolation and Characterization of Lup-20(29)-ene-3, 28- diol (Betulin) from the Stem-Bark of Adenium obesum (Apocynaceae) [O] . A Tijjani, IG Ndukwe, RG Ayo 2012

机译：从腺瘤的茎树（Anocynaceae）的茎树上分离和表征Lup-20（29）-3,28-二醇（桦木蛋白）（apocynaceae）

Synthesis of Betulin 28-(2-Bromoacetate) Conjugates with Uracil and its Methyl-Substituted Homologs

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