Effect of photodynamic therapy on inflammatory acne using 3% liposomal 5-aminolevulinic acid emulsion and intense-pulsed light: A pilot study

摘要

Photodynamic therapy (PUT) is known as an effective treatment modality for acne. It is important that an exogenous photosensitizer is delivered to target tissues for PDT. Aminolevulinic acid (ALA) is one of the most useful pro-photosensitizers approved for PDT. There are several studies reporting good effect of 20% 5-ALA PDT on inflammatory acne. However, hydrophilic ALA requires some enhancers, such as desferrioxamine, dimethylsulfoxide and edetic acid disodium salt, for more effective skin penetration.