Aliskiren Alone or in Combination With Hydrochlorothiazide in Hispanic/Latino Patients With Systolic Blood Pressure 160mmHg to <180mmHg (Aliskiren Alone or in Combination With Hydrochlorothiazide in Patients With Stage 2 Hypertension to Provide Quick Intensive Control of Blood Pressure [ACQUIRE] Substudy)

摘要

In a prespecified subgroup analysis of a 12-week multinational, randomized, double-blind, parallel-group trial, self-identified Hispanic/Latino adult men and women with systolic blood pressure 160mmHg to 179mmHg received combination aliskiren/hydrochlorothiazide (HCT) 150/12.5mg or aliskiren 150mg (force-titrated to 300/25mg and 300mg, respectively, at week 1). At week 12, combination aliskiren/HCT provided greater reduction in mean sitting systolic blood pressure from baseline, the primary efficacy variable, compared with aliskiren monotherapy (-32.6mmHg vs -19.6mmHg; P<.0001). Differences in mean sitting diastolic blood pressure reductions followed a similar pattern (-13.5mmHg vs -7.1mmHg; P<.0001). Notable blood pressure reductions were evident at week 1 in both treatment groups, with near-maximal effects reached by week 8. Results were consistent regardless of country of residence. Both treatments were well tolerated. Aliskiren alone or in combination with HCT is safe and effective in Hispanic/Latino patients with stage 2 hypertension. Combination aliskiren/HCT produced greater blood pressure reductions than aliskiren monotherapy.