Assessment of in vivo 5-lipoxygenase activity by analysis of leukotriene B_4 in saliva: Effects of treatment with zileuton

摘要

Leukotrienes (LTs) generated by the 5-lipoxygenase (5-LO) pathway are important inflammatory mediators in asthma and allergy, and pharmacologic intervention with 5-LO products is one therapeutic alternative in asthma and rhinitis. As circulating levels of LTs are very low and plasma concentrations of LTs cannot be determined reliably with current methods, there is a need for other biomarkers to monitor 5-LO activity in vivo. Although previous studies have indicated that baseline urinary LTE_4 is a#