Association of IL4R polymorphisms with Stevens-Johnson syndrome

摘要

To the Editor:Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are acute-onset mucocutaneous diseases induced by infectious agents and/or inciting drugs. Although the pathobiological mechanisms underlying the onset of SJS/TEN have not been fully established, the extreme rarity of cutaneous and ocular surface reactions to drug therapies led us to suspect individual susceptibility. In the acute stage, patients with SJS/TEN manifest vesiculobullous skin lesions, severe conjunctivitis, and persistent corneal epithelial defects. In the chronic stage, ocular surface complications such as conjunctival invasion into the cornea due to corneal epithelial stem cell deficiency persist (Fig 1, A). We observed that more than 95% of patients with SJS/TEN with ocular surface complications had lost their fingernails in the acute or subacute stage and that some continue to have transformed nails even after healing of the skin lesions (Fig 1, B). Our study focused on patients with SJS/TEN accompanied by ocular surface complications. #