Autocrine hemokinin-1 functions as an endogenous adjuvant for IgE-mediated mast cell inflammatory responses

摘要

Background: Efficient development of atopic diseases requires interactions between allergen and adjuvant to initiate and amplify the underlying inflammatory responses. Substance P (SP) and hemokinin-1 (HK-1) are neuropeptides that signal through the neurokinin-1 receptor (NK1R) to promote inflammation. Mast cells initiate the symptoms and tissue effects of atopic disorders, secreting TNF and IL-6 after Fc epsilon RI cross-linking by antigen-IgE complexes (Fc epsilon RI-activated mast cells [Fc epsilon RI-MCs]). Additionally, MCs express the NK1R, suggesting an adjuvant role for NK1R agonists in Fc epsilon RI-MC-mediated pathologies; however, in-depth research addressing this relevant aspect of MC biology is lacking.