House dust mite models: Will they translate clinically as a superior model of asthma?

摘要

House dust mite (HDM) is a common allergen associated with allergic asthma. Consequently, HDM extracts are being more widely used to model the allergic airway phenotype. Unfortunately, as pointed out by Birrell et al there is a paucity of preclin-ical data demonstrating that HDM elicits classic features of allergic asthma, namely, the early and late asthmatic responses.