The importance of reducing SFA intake to limit CHD risk.Comments Comment on: Br J Nutr. 2011 Oct;106(7):961-3; PMID: 21906408

摘要

In a recently published guest editorial, Pedersen et al. (1) discuss the importance of reducing the intake of SFA to limit CHD risk. The authors emphasise the shortcomings of results from prospective cohort studies and discuss other lines of evidence. This evidence leads the authors to conclude that substantial bene?ts can be found from reducing the intake of SFA. Results from the different lines of evidence in the way presented by Pedersen et al., however, raise several questions. First, the importance of lowering SFA intakes to lower blood LDL-cholesterol levels is emphasised. However, a metaanalysis of controlled trials examining the effects of replacing carbohydrates with different types of fatty acids showed that SFA not only increase LDL-cholesterol, but also HDLcholesterol compared to carbohydrates and that the ratio of total:HDL-cholesterol was not changed by this exchange (2) .