A new approach to isoindolobenzazepines via a ring-expansion of isoindoloisoquinoline: Synthesis of lennoxamine and chilenine

摘要

A convenient short-step synthesis of lennoxamine 1 and chilenine 2 is described. The key steps are the preparation of an acyliminium ion precursor and a novel expansion of the six-membered ring to a seven-membered ring. (C) 1999 Elsevier Science Ltd. All rights reserved. [References: 33]