VERSATILE SYNTHESIS OF L-ALPHA-AMINO ACIDS STEREOSPECIFICALLY LABELLED ON THE BETA-CARBON ATOM

摘要

Inversion of the stereochemistry at the alpha-centre of stereospecifically labelled samples of (2S)-isoserine (7) using a sequence involving an intramolecular substitution reaction has allowed synthesis of the stereospecifically labelled aziridines (19) to be completed. These are synthons for a very versatile preparation of L-amino acids which are stereospecifically labelled at the beta-carbon atom. Copyright (C) 1996 Elsevier Science Ltd [References: 9]