The Vilsmeier cyclization of 2'-azido and 2'-aminochalcones- a mild one pot synthesis of 2-aryl-4-chloroquinoline and its N-formyl-1,2-dihydro derivatives

摘要

The Vilsmeier cyclizatio of 2'-aminochalcones providess a mild one pot synthesis of 2-aryl-4-chloro-N-formyl-1,2-dihydro-quinolines.The scope of the reaction has ben extended for the synthesis of quinolines themselves,by replacing 2'-aminochalones with 2'-azidochalcones as the starting material.The yields are reasonably good and a plausible mechanism for the formation of the products in each case has been discussed.