A facile synthetic method for chiral 1,2-epoxides and the total synthesis of chiral pheromone epoxides

摘要

Chiral 1,2-epoxy-3-alkanol tosylates were successfully synthesized from alkynols in three steps using the Sharpless AD reaction as a key step in good yields. Two chiral insect pheromone epoxides were smoothly obtained from the corresponding key intermediate.