首页> 外文期刊>Peritoneal dialysis international: Journal of the International Society for Peritoneal Dialysis >Clinical outcomes and quality of life in elderly patients on peritoneal dialysis versus hemodialysis.
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Clinical outcomes and quality of life in elderly patients on peritoneal dialysis versus hemodialysis.

机译:老年患者腹膜透析与血液透析的临床结局和生活质量。

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OBJECTIVE: To compare clinical outcomes and quality of life (QOL) in elderly patients on peritoneal dialysis (PD) and hemodialysis (HD) in the North Thames Dialysis Study. DESIGN: A 12-month prospective cohort study. SETTING: Four hospital-based renal units in London, UK. PATIENTS: 174 patients that were 70 years or older at the start of dialysis, separated into two cohorts: 78 new patients (36 PD, 42 HD) that were recruited after 90 days of chronic dialysis; and 96 stock patients (42 PD, 54 HD) that were already on dialysis during the recruitment period. MAIN OUTCOME MEASURES: 12-month survival and hospitalization rate, and QOL assessed at baseline and at 6 and 12 months by the SF-36 and the Symptoms/Problems scale of the Kidney Disease Quality of Life Questionnaire (KDQOL). RESULTS: Peritoneal dialysis and HD patients were similar for sociodemographic and clinical characteristics. Annual mortality and hospitalization rates in PD versus HD patients were 26.1 versus 26.4 deaths/100 person-years and 1.9 versus 2.0 admissions/person-year, respectively. Adjusted relative risks showed no effect of modality on clinical outcomes. Multiple linear regression analyses of OOL at baseline showed similar SF-36 scores between PD and HD patients, but higher KDQOL scores in PD patients (3.5 points higher, 95% confidence interval 0.3-6.6). There was, however, no effect of dialysis modality on QOL at 6 or 12 months. CONCLUSIONS: Clinical outcomes and QOL are similar in elderly people on PD and HD. Peritoneal dialysis is a viable option for more than a carefully selected minority of elderly people requiring dialysis.
机译:目的:比较北泰晤士河透析研究中老年患者腹膜透析(PD)和血液透析(HD)的临床结局和生活质量(QOL)。设计:一项为期12个月的前瞻性队列研究。地点:英国伦敦的四个医院肾单位。患者:透析开始时有174名年龄在70岁或以上的患者,分为两个队列:慢性透析90天后招募的78例新患者(36 PD,42 HD)。在招募期间已经透析的96例库存患者(42 PD,54 HD)。主要观察指标:12个月生存率和住院率,并通过SF-36和《肾脏疾病生活质量问卷》(KDQOL)的症状/问题量表在基线,6和12个月评估QOL。结果:腹膜透析和HD患者的社会人口统计学和临床​​特征相似。 PD与HD患者的年死亡率和住院率分别为每100人年26.1例死亡和26.4例死亡,每人年1.9例与2.0例死亡。调整后的相对危险度表明治疗方式对临床结局无影响。基线时OOL的多重线性回归分析显示,PD和HD患者之间的SF-36得分相似,但PD患者中的KDQOL得分更高(更高3.5分,95%置信区间0.3-6.6)。然而,在6个月或12个月时,透析方式对生活质量没有影响。结论:PD和HD的老年人的临床结局和QOL相似。对于经过精心挑选的少数需要透析的老年人而言,腹膜透析是可行的选择。

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