A pediatric case of ketamine-associated cystitis (Letter-to-the-Editor RE: Shahani R, Streutker C, Dickson B, et al: Ketamine-associated ulcerative cystitis: a new clinical entity. Urology 69: 810-812, 2007).

摘要

We read with great interest the recent article by Shahani et al1 on ketamine-associated ulcerative cystitis. The authors described this new entity in a series of 9 patients who were daily recreational ketamine users. Their symptoms improved with the cessation of ketamine use.Ketamine is also increasingly used orally as a third-line agent in chronic neuropathic pain, for its N-methyl-D-aspartate (NMDA) antagonist effect. It has been shown to be effective in subgroups of patients; a review and guidelines for its use have were published in 2003. Until now, however, ulcerative or eosinophilic cystitis has only been described in recreational users and not chronic pain patients1'3 except for 3 adult patients who have been briefly described on a palliative care drugs mailing list.