First-trimester growth discordance and adverse pregnancy outcome in dichorionic twins.

摘要

To evaluate the association between first-trimester growth discordance and adverse pregnancy outcome in dichorionic twin pregnancies.This was a retrospective cohort study of consecutive women with dichorionic twin pregnancies undergoing an ultrasound scan at our institution between 7 and 14?weeks' gestation. Study groups were defined by the presence or absence of ≥?11% crown-rump length (CRL) discordance. Pregnancies were excluded if one twin was dead on initial ultrasound or if a termination was performed. The primary outcome was loss of one or both fetuses before 20?weeks. Secondary outcomes included fetal anomaly, fetal demise after 20?weeks (stillbirth), small-for-gestational-age (SGA) at birth, admission to the neonatal intensive care unit (NICU) and preterm delivery before 34?weeks.Of 805 dichorionic twin pregnancies undergoing first-trimester ultrasound, 610 met the inclusion criteria. Eighty-six had ≥?11% CRL discordance and, of these, nine (10.5%) had a fetal loss at?