Self-injurious and aggressive behavior associated with a tacrolimus overdose.

摘要

-TO THE EDITOR: Patients treated with tacrolimus (FK506) are frequently subject to neuropsychiatric complications, which commonly include insomnia, anxiety, and mood disorders. This report describes a case of self-injurious aggressive behavior induced by accidental acute overdose of tacrolimus (TCL) during treatment to prevent allograft rejection after liver transplantation, which has never been reported. TCL has been shown to inhibit the expression of interleukin-2 in T cells, which results in the inhibition of T-cell growth and proliferation, which may explain the adverse event described below.