Antidepressant activity of nociceptin/orphanin FQ receptor antagonists in the mouse learned helplessness

摘要

Rationale Pharmacological and genetic evidence support antidepressant-like effects elicited by the blockade of the NOP receptor. The learned helplessness (LH) model employs uncontrollable and unpredictable electric footshocks as a stressor stimulus to induce a depressive-like phenotype that can be reversed by classical antidepressants.