Smell Intensity Monitoring Using Metal Oxide Semiconductor Odor Sensors during Intravenous Olfaction Test

摘要

The intravenous olfaction test using prosultiamine (PST) solution is simple to perform and has been used clinically in Japan.We monitored intranasal intensity of smell continuously in real time under various conditions of administration using metal oxide semiconductor odor sensors and established an optimal PST injection procedure.In this study,we found that 1) although there was fluctuation in the pattern of intensity of increase in smell in the PSToriginal solution test,the pattern of increase in intranasal smell intensity could be stabilized by prolonging the injection time to 40 s and 2) dilution of PST with physiological saline was effective in preventing angialgia during intravenous injection.It appears that PSTadministration is best performed by adding 10 ml of saline to 10 mg (2 ml) of PSTand injecting the resulting 12-ml solution (6x dilution) and that the best respiratory cycle for testing is once in every 2 s.