Anthocleistenolide, A New Rearranged Nor-Secoiridoid Derivative from the Stem Bark of Anthocleista vogelii.

摘要

A new rearranged nor-secoiridoid, anthocleistenolide ( 1), along with the known 1-hydroxy-3,7-dimethoxyxanthone ( 2), 1-hydroxy-3,7,8-trimethoxyxanthone ( 3), 7alpha-hydroxysitosterol ( 4) and sitosterol 3- O-beta- D-glucopyranoside ( 5), were isolated from the stem bark of ANTHOCLEISTA VOGELII. Their structures were elucidated on the basis of spectral studies and comparison with published data. Compounds 1 - 3 and 5 were evaluated for their antibacterial and antifungal activities. Relatively low anti-staphylococcal (MIC = 200 mug/mL against STAPHYLOCOCCUS AUREUS) and anti-enterococcal (MIC = 100 mug/mL against ENTEROCOCCUS FAECALIS) activities were observed for 1, while compounds 2 and 3 were active against CANDIDA PARAPSILOSIS (MIC = 200 mug/mL for 2 and 25 mug/mL for 3). Compound 5 was inactive against all the bacterial and fungal species used.