首页> 外文期刊>Plant physiology >Molecular steps in the immune signaling pathway evoked by plant elicitor peptides: Ca~(2+)-dependent protein kinases, nitric oxide, and reactive oxygen species are downstream from the early Ca~(2+) signal
【24h】

Molecular steps in the immune signaling pathway evoked by plant elicitor peptides: Ca~(2+)-dependent protein kinases, nitric oxide, and reactive oxygen species are downstream from the early Ca~(2+) signal

机译:植物激发子肽诱发的免疫信号传导途径中的分子步骤:Ca〜(2+)依赖性蛋白激酶,一氧化氮和活性氧物种位于早期Ca〜(2+)信号的下游

获取原文
获取原文并翻译 | 示例
       

摘要

Endogenous plant elicitor peptides (Peps) can act to facilitate immune signaling and pathogen defense responses. Binding of these peptides to the Arabidopsis (Arabidopsis thaliana) plasma membrane-localized Pep receptors (PEPRs) leads to cytosolic Ca~(2+) elevation, an early event in a signaling cascade that activates immune responses. This immune response includes the amplification of signaling evoked by direct perception of pathogen-associated molecular patterns by plant cells under assault. Work included in this report further characterizes the Pep immune response and identifies new molecular steps in the signal transduction cascade. The PEPR coreceptor BRASSINOSTEROID-INSENSITIVE1 Associated Kinase1 contributes to generation of the Pep-activated Ca~(2+) signal and leads to increased defense gene expression and resistance to a virulent bacterial pathogen. Ca~(2+)-dependent protein kinases (CPKs) decode theCa~(2+) signal, also facilitatingdefense gene expression andenhancedresistance to the pathogen. Nitric oxide and reduced nicotinamide adenine dinucleotide phosphate oxidase-dependent reactive oxygen species generation (due to the function of Respiratory Burst Oxidase Homolog proteins D and F) are also involved downstream from the Ca~(2+) signal in the Pep immune defense signal transduction cascade, as is the case with BRASSINOSTEROID-INSENSITIVE1 Associated Kinase1 and CPK5, CPK6, and CPK11. These steps of the pathogen defense response are required for maximal Pep immune activation that limits growth of a virulent bacterial pathogen in the plant. We find a synergism between function of the PEPR and Flagellin Sensing2 receptors in terms of both nitric oxide and reactive oxygen species generation. Presented results are also consistent with the involvement of the secondary messenger cyclic GMP and a cyclic GMP-activated Ca~(2+)-conducting channel in the Pep immune signaling pathway.
机译:内源性植物激发子肽(Peps)可以促进免疫信号传导和病原体防御反应。这些肽与拟南芥(Arabidopsis thaliana)质膜定位的Pep受体(PEPRs)的结合导致胞质Ca〜(2+)升高,这是激活免疫反应的信号级联反应的早期事件。这种免疫反应包括在侵害下植物细胞对病原体相关分子模式的直接感知引起的信号转导的放大。本报告中的工作进一步表征了Pep免疫应答,并确定了信号转导级联反应中的新分子步骤。 PEPR核心受体BRASSINOSTEROID-INSENSITIVE1相关激酶1有助于Pep激活的Ca〜(2+)信号的产生,并导致防御基因表达增加和对强力细菌病原体的抵抗力。 Ca〜(2+)依赖性蛋白激酶(CPKs)解码Ca〜(2+)信号,也促进防御基因的表达和对病原体的抗性。一氧化氮和减少的烟酰胺腺嘌呤二核苷酸磷酸氧化酶依赖性活性氧的产生(由于呼吸爆发氧化酶同源蛋白D和F的功能)也参与Pep免疫防御信号转导中Ca〜(2+)信号的下游级联,例如与BRASSINOSTEROID-INSENSITIVE1相关的激酶1和CPK5,CPK6和CPK11的情况。这些病原体防御反应的步骤是最大Pep免疫激活所必需的,该激活可限制植物中有毒细菌病原体的生长。我们发现一氧化氮和活性氧物种生成方面,PEPR和鞭毛蛋白Sensing2受体的功能之间存在协同作用。提出的结果也与次级信使环GMP和环GMP激活的Ca〜(2+)传导通道参与Pep免疫信号通路一致。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号