Molecular and Physiological Bases of the K~+ Circulation in the Mammalian Inner Ear

摘要

Endolymphy, the extracellular solution in cochlea, contains 150 mM K~+ and exhibits a potential of approximately +80 mV relative to neighboring extracellular spaces. This unique situation, essential for hearing, is maintained by K~+ circulation from perilymph to endolymph through the cochlear lateral wall. Recent studies have identified ion-trans-port molecules involved in the K~+ circulation and their pathophysiological relevance.