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Introductions and early spread of SARS-CoV-2 in the New York City area

机译：纽约市区SARS-COV-2的介绍及早期传播

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摘要

New York City (NYC) has emerged as one of the epicenters of the current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. To identify the early transmission events underlying the rapid spread of the virus in the NYC metropolitan area, we sequenced the virus that causes coronavirus disease 2019 (COVID-19) in patients seeking care at the Mount Sinai Health System. Phylogenetic analysis of 84 distinct SARS-CoV-2 genomes indicates multiple, independent, but isolated introductions mainly from Europe and other parts of the United States. Moreover, we found evidence for community transmission of SARS-CoV-2 as suggested by clusters of related viruses found in patients living in different neighborhoods of the city.
机译：纽约市（纽约）已成为目前严重急性呼吸综合征冠状病毒2（SARS-COV-2）大流行的震中之一。为了确定纽约市区迅速传播的早期传输事件，在纽约市区地区测序，导致冠状病毒疾病2019（Covid-19）的病毒在山脉山上卫生系统寻求护理的病毒。 84个不同的SARS-COV-2基因组的系统发育分析表明，主要来自欧洲和其他地区的多个，独立，但孤立的介绍。此外，我们发现SARS-COV-2的社区传播的证据，如患有城市不同社区的患者中发现的相关病毒簇的簇。

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  • 来源
    《Science》 |2020年第6501期|297-301|共5页
  • 作者

    Gonzalez-Reiche Ana S.; Hernandez Matthew M.; Sullivan Mitchell J.; Ciferri Brianne; Alshammary Hala; Obla Ajay; Fabre Shelcie; Kleiner Giulio; Polanco Jose; Khan Zenab; Alburquerque Bremy; van de Guchte Adriana; Dutta Jayeeta; Francoeur Nancy; Melo Betsaida Salom; Oussenko Irina; Deikus Gintaras; Soto Juan; Sridhar Shwetha Hara; Wang Ying-Chih; Twyman Kathryn; Kasarskis Andrew; Altman Deena R.; Smith Melissa; Sebra Robert; Aberg Judith; Krammer Florian; Garcia-Sastre Adolfo; Luksza Marta; Patel Gopi; Paniz-Mondolfi Alberto; Gitman Melissa; Sordillo Emilia Mia; Simon Viviana; van Bakel Harm;

  • 作者单位

    Icahn Sch Med Mt Sinai Dept Genet & Genom Sci New York NY 10029 USA;

    Icahn Sch Med Mt Sinai Dept Microbiol New York NY 10029 USA|Icahn Sch Med Mt Sinai Grad Sch Biomed Sci New York NY 10029 USA;

    Icahn Sch Med Mt Sinai Dept Genet & Genom Sci New York NY 10029 USA;

    Icahn Sch Med Mt Sinai Dept Genet & Genom Sci New York NY 10029 USA;

    Icahn Sch Med Mt Sinai Dept Microbiol New York NY 10029 USA;

    Icahn Sch Med Mt Sinai Dept Genet & Genom Sci New York NY 10029 USA;

    Icahn Sch Med Mt Sinai Dept Pathol Mol & Cell Based Med Clin Microbiol Lab New York NY 10029 USA;

    Icahn Sch Med Mt Sinai Dept Microbiol New York NY 10029 USA;

    Icahn Sch Med Mt Sinai Dept Genet & Genom Sci New York NY 10029 USA|Icahn Sch Med Mt Sinai Dept Microbiol New York NY 10029 USA;

    Icahn Sch Med Mt Sinai Dept Genet & Genom Sci New York NY 10029 USA;

    Icahn Sch Med Mt Sinai Dept Genet & Genom Sci New York NY 10029 USA|Icahn Sch Med Mt Sinai Grad Sch Biomed Sci New York NY 10029 USA;

    Icahn Sch Med Mt Sinai Dept Genet & Genom Sci New York NY 10029 USA;

    Icahn Sch Med Mt Sinai Dept Genet & Genom Sci New York NY 10029 USA;

    Icahn Sch Med Mt Sinai Dept Genet & Genom Sci New York NY 10029 USA;

    Icahn Sch Med Mt Sinai Dept Genet & Genom Sci New York NY 10029 USA|Icahn Sch Med Mt Sinai Icahn Inst Data Sci & Genom Technol New York NY 10029 USA;

    Icahn Sch Med Mt Sinai Dept Genet & Genom Sci New York NY 10029 USA|Icahn Sch Med Mt Sinai Icahn Inst Data Sci & Genom Technol New York NY 10029 USA;

    Icahn Sch Med Mt Sinai Dept Genet & Genom Sci New York NY 10029 USA|Icahn Sch Med Mt Sinai Icahn Inst Data Sci & Genom Technol New York NY 10029 USA;

    Icahn Sch Med Mt Sinai Dept Genet & Genom Sci New York NY 10029 USA|Icahn Sch Med Mt Sinai Icahn Inst Data Sci & Genom Technol New York NY 10029 USA;

    Icahn Sch Med Mt Sinai Dept Genet & Genom Sci New York NY 10029 USA|Icahn Sch Med Mt Sinai Icahn Inst Data Sci & Genom Technol New York NY 10029 USA;

    Icahn Sch Med Mt Sinai Dept Genet & Genom Sci New York NY 10029 USA|Icahn Sch Med Mt Sinai Icahn Inst Data Sci & Genom Technol New York NY 10029 USA;

    Mt Sinai Hlth Syst Mt Sinai Data Off New York NY 10029 USA;

    Icahn Sch Med Mt Sinai Dept Genet & Genom Sci New York NY 10029 USA|Icahn Sch Med Mt Sinai Icahn Inst Data Sci & Genom Technol New York NY 10029 USA|Mt Sinai Hlth Syst Mt Sinai Data Off New York NY 10029 USA;

    Icahn Sch Med Mt Sinai Dept Genet & Genom Sci New York NY 10029 USA|Icahn Sch Med Mt Sinai Dept Med Div Infect Dis New York NY 10029 USA;

    Icahn Sch Med Mt Sinai Dept Genet & Genom Sci New York NY 10029 USA|Icahn Sch Med Mt Sinai Icahn Inst Data Sci & Genom Technol New York NY 10029 USA;

    Icahn Sch Med Mt Sinai Dept Genet & Genom Sci New York NY 10029 USA|Icahn Sch Med Mt Sinai Icahn Inst Data Sci & Genom Technol New York NY 10029 USA|Icahn Sch Med Mt Sinai Black Family Stem Cell Inst New York NY 10029 USA|Sema4 Stamford CT 06902 USA;

    Icahn Sch Med Mt Sinai Dept Med Div Infect Dis New York NY 10029 USA;

    Icahn Sch Med Mt Sinai Dept Microbiol New York NY 10029 USA|Icahn Sch Med Mt Sinai Global Hlth & Emerging Pathogens Inst New York NY 10029 USA;

    Icahn Sch Med Mt Sinai Dept Microbiol New York NY 10029 USA|Icahn Sch Med Mt Sinai Dept Med Div Infect Dis New York NY 10029 USA|Icahn Sch Med Mt Sinai Global Hlth & Emerging Pathogens Inst New York NY 10029 USA|Icahn Sch Med Mt Sinai Tisch Canc Inst New York NY 10029 USA;

    Icahn Sch Med Mt Sinai Dept Genet & Genom Sci New York NY 10029 USA|Icahn Sch Med Mt Sinai Dept Oncol Sci New York NY 10029 USA;

    Icahn Sch Med Mt Sinai Icahn Inst Data Sci & Genom Technol New York NY 10029 USA;

    Icahn Sch Med Mt Sinai Grad Sch Biomed Sci New York NY 10029 USA;

    Icahn Sch Med Mt Sinai Grad Sch Biomed Sci New York NY 10029 USA;

    Icahn Sch Med Mt Sinai Grad Sch Biomed Sci New York NY 10029 USA;

    Icahn Sch Med Mt Sinai Dept Microbiol New York NY 10029 USA|Icahn Sch Med Mt Sinai Icahn Inst Data Sci & Genom Technol New York NY 10029 USA|Mt Sinai Hlth Syst Mt Sinai Data Off New York NY 10029 USA;

    Icahn Sch Med Mt Sinai Dept Genet & Genom Sci New York NY 10029 USA|Icahn Sch Med Mt Sinai Black Family Stem Cell Inst New York NY 10029 USA;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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