As we depart on vacation, we're likely to get a crash course on what happens when traffic is not properly directed. The global transportation system is a marvel, carrying people and goods from Toledo to Timbuktu and all points between, but just try telling that to someone stuck in a traffic jam between Philadelphia and New York with three kids in a minivan. Just as the transportation system depends on the smooth operation of a complex mix of machinery and personnel, so the proper functioning of our bodies' cells—and ultimately of our bodies—depends on proper traffic direction. This travel advisory is well illustrated by the report from Bilder and colleagues on page 113 of this issue. The authors reveal surprising connections between three seemingly different cellular events: protein transport, cell polarity, and the regulation of cell proliferation.
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