Stage-specific modulation of skeletal myogenesis by inhibitors of nuclear deacetylases

摘要

Nuclear acetyltransferases promote and deacetylases inhibit skel- etal muscle-gene expression, suggesting the potential effective- ness of deacetylase inhibitors (DIs) in modulating skeletal myo- genesis. Surprisingly, previous studies have indicated that DIs suppress myogenesis. The recent observations that histone deacetylases associate with the muscle-regulatory proteins MyoD and MEF2C only in undifferentiated myoblasts prompted us to evaluate the effect of DIs at distinct stages of the myogenic program. We found that exposure of established rodent and human muscle cells to distinct DIs has stage-specific effects.