Molecular dissection of hippocampal theta-burst pairing potentiation

摘要

Long-term potentiation (LTP) of synaptic efficacy in the hippocam- pus is frequently induced by tetanic stimulation of presynaptic afferents or by pairing low frequency stimulation with postsyn- aptic depolarization. Adult (P42) GluR-A~-/- mice largely lack these forms of LTP. LTP in wt mice can also be induced by coincident pre- and postsynaptic action potentials, where an initial rapid compo- nent is expressed but a substantial fraction of the potentiation develops with a delayed time course. We report here that this stimulation protocol, delivered at theta frequency (5 Hz), induces LTP in GluR-A~-/- mice in which the initial component is substan- tially reduced.