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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Kinetic mechanism for viral dsRNA length discrimination by MDA5 filaments
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Kinetic mechanism for viral dsRNA length discrimination by MDA5 filaments

机译：MDA5细丝识别病毒dsRNA长度的动力学机制

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摘要

Successful host defense against viral infection depends on efficient and proper recognition of an invading virus by a set of germline-encoded pattern-recognition receptors in the innate immune system. One such receptor in vertebrates is an RNA helicase, melanoma differentiation-associated gene 5 (MDA5).
机译：成功的宿主防御病毒感染的方法取决于先天免疫系统中一组种系编码的模式识别受体对入侵病毒的有效和正确识别。脊椎动物中的一种此类受体是RNA解旋酶，即黑素瘤分化相关基因5（MDA5）。

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    Alys Peisley; Myung Hyun Jo; Cecilie Lin; Bin Wu; McGhee Orme-Johnson; Thomas Walz; Sungchul Hohng; Sun Hur;

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    Departments of Biological Chemistry and Molecular Pharmacology and Harvard Medical School, Boston,MA 02115,Program in Cellular and Molecular Medicine, Children's Hospital Boston, Boston, MA 02115;

    Department of Physics and Astronomy, Seoul National University, Seoul, 151-747, Korea;

    Departments of Cell Biology and Harvard Medical School, Boston,MA 02115;

    Departments of Biological Chemistry and Molecular Pharmacology and Harvard Medical School, Boston,MA 02115,Program in Cellular and Molecular Medicine, Children's Hospital Boston, Boston, MA 02115;

    Program in Cellular and Molecular Medicine, Children's Hospital Boston, Boston, MA 02115;

    Departments of Cell Biology and Harvard Medical School, Boston,MA 02115,Departments of Howard Hughes Medical Institute, Harvard Medical School, Boston,MA 02115;

    Department of Physics and Astronomy, Seoul National University, Seoul, 151-747, Korea;

    Departments of Biological Chemistry and Molecular Pharmacology and Harvard Medical School, Boston,MA 02115,Program in Cellular and Molecular Medicine, Children's Hospital Boston, Boston, MA 02115;

  • 收录信息 美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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