Lipid targeting domain with dual-membrane specificity that expands the diversity of intracellular targeting reactions

摘要

In cell signaling pathways, many critical on-off switching events occur on membrane surfaces. Such switching events are often regulated by lipid targeting domains that recruit their parent signaling proteins from cytoplasm to the appropriate membrane surface during the event and then release from the membrane when the event ends. Once bound to their target membrane, the recruited signaling proteins are activated, at least in part, by enhanced accessibility to membrane-associated effector proteins and/or lipids (Fig. L4). Lipid targeting domains have evolved sophisticated chemical recognition strategies to discriminate among diverse types of membranes exposed to the cytoplasm, enabling specific binding to one membrane.