It is April 2021. Tarou Yamada is born in Tokyo, making headlines around the world. "The miracle boy," some newspapers dub him. That's because Tarou's father is unable to produce sperm because of a mutation on his Y-chromosome. He is thus, in theory, completely infertile. Yet genetic tests confirm that Tarou is his son. To make Tarou's conception possible, a fertility clinic took stem cells from the father, corrected the Y-chromosome mutation using CRISPR genome editing and then derived sperm cells from the corrected cells. Those edited sperm cells where then used to fertilise the mother's eggs, cementing the change into all of his nuclear DNA. In other words, Tarou Yamada is the first person whose genome has been edited.
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