Role for BID in immunity

摘要

The proapoptotic BCL2-family protein BID has been found to modulate inflammation and innate immunity in intestinal epithelial cells, independently of its role in apoptosis. It acts through NODI and NOD2, the cytosolic sensors for bacterial peptidoglycans. This work points to BID as a possible therapeutic target for immune-mediated inflammatory conditions such as inflammatory bowel disease.