Dual-action bone protection

摘要

Semaphorin 3A (Sema3A), a secreted protein involved in the regulation of axonal growth, is identified here as an osteoprotective factor that both inhibits osteoclastic bone resorption and promotes osteoblastic bone formation. The binding of Sema3A to its receptor neuropilin-1 inhibits osteoclast differentiation, while stimulating osteoblast and inhibiting adipocyte differentiation.