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Sema3A regulates bone-mass accrual through sensory innervations

机译：Sema3A通过感觉神经调节骨质积聚

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摘要

Semaphorin 3A (Sema3 A) is a diffusible axonal chemorepellent that has an important role in axon guidance~(1-5). Previous studies have demonstrated that Sema3a~(-1-) mice have multiple developmental defects due to abnormal neuronal innervations6'7. Here we show in mice that Sema3A is abundantly expressed in bone, and cell-based assays showed that Sema3A affected osteoblast differentiation in a cell-autonomous fashion. Accordingly, Sema3a~ (-1-)mice had a low bone mass due to decreased bone formation. However, osteoblast-spedfic Sema3A-deficknt mice (Sema3acolt~(-1-) and Sema3a_(osx)mice)had normal bone mass, even though the expression of Sema3A in bone was substantially decreased.%SerfIaphorins是神经系统、器官和血管的发rn育中以及免疫中所涉及的可扩散蛋白。造骨rn细胞和破骨细胞表达Semaptlorin家族的成rn员，而且最近人们曾发现，Semaphorin 3Arn(Sema3A)能通过在局部发挥作用来调控骨rn头重塑。在这项研究中，Toru Fukuda等人发rn现，Serrla3A通过调制感觉神经发育来在活rn体中间接调控骨头重塑。
机译：Semaphorin 3A (Sema3 A) is a diffusible axonal chemorepellent that has an important role in axon guidance~(1-5). Previous studies have demonstrated that Sema3a~(-1-) mice have multiple developmental defects due to abnormal neuronal innervations6'7. Here we show in mice that Sema3A is abundantly expressed in bone, and cell-based assays showed that Sema3A affected osteoblast differentiation in a cell-autonomous fashion. Accordingly, Sema3a~ (-1-)mice had a low bone mass due to decreased bone formation. However, osteoblast-spedfic Sema3A-deficknt mice (Sema3acolt~(-1-) and Sema3a_(osx)mice)had normal bone mass, even though the expression of Sema3A in bone was substantially decreased.%SerfIaphorins是神经系统、器官和血管的发rn育中以及免疫中所涉及的可扩散蛋白。造骨rn细胞和破骨细胞表达Semaptlorin家族的成rn员，而且最近人们曾发现，Semaphorin 3Arn(Sema3A)能通过在局部发挥作用来调控骨rn头重塑。在这项研究中，Toru Fukuda等人发rn现，Serrla3A通过调制感觉神经发育来在活rn体中间接调控骨头重塑。

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  • 来源
    《Nature》 |2013年第7450期|490-493|共4页
  • 作者

    Tom Fukuda; Shu Takeda; Ren Xu; Hiroki Ochi; Satoko Sunamura; Tsuyoshi Sato; Shinsuke Shibata; Yutaka Yoshida; Zirong Gu; Ayako Kitnura; Chengshan Ma; Cheng Xu; Waka Bando; Koji Fujita; Kenichi Shinomiya; Takashi Hirai; Yoshinori Asou; Mitsuhiro Enomoto; Hideyuki Okano; Atsushi Okawa; Hiroshi Itoh;

  • 作者单位

    Department of Internal Medicine, School of Medicine, Keio University, Shinanomachi 35, Shinjyuku-ku, Tokyo 160-8582, Japan;

    Department of Internal Medicine, School of Medicine, Keio University, Shinanomachi 35, Shinjyuku-ku, Tokyo 160-8582, Japan;

    Department of Orthopedic Surgery, Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo 113-8549. Japan,Global Center of Excellence (GCOE) Program, International Research Center for Molecular Science in Tooth and Bone Diseases, Yushima 1-5-45,Bunkyo-ku, Tokyo 113-8549, Japan;

    Department of Internal Medicine, School of Medicine, Keio University, Shinanomachi 35, Shinjyuku-ku, Tokyo 160-8582, Japan;

    Department of Internal Medicine, School of Medicine, Keio University, Shinanomachi 35, Shinjyuku-ku, Tokyo 160-8582, Japan;

    epartment of Oral and Maxillofacial Surgery, Saitama Medical University, Morohongo 38, Moroyama-machi, Iruma-gun, Saitama 350-0495, Japan;

    Department of Physiology, School of Medicine, Keio University, Shinanomachi 35, Shinjyuku-ku, Tokyo 160-8582, Japan;

    Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati,Ohio 45229, USA;

    Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati,Ohio 45229, USA;

    Department of Orthopedic Surgery, Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo 113-8549. Japan,Hard Tissue Genome Research Center, Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo 113- 8549, Japan;

    Department of Orthopedic Surgery, Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo 113-8549. Japan,Global Center of Excellence (GCOE) Program, International Research Center for Molecular Science in Tooth and Bone Diseases, Yushima 1-5-45,Bunkyo-ku, Tokyo 113-8549, Japan;

    Department of Orthopedic Surgery, Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo 113-8549. Japan,Global Center of Excellence (GCOE) Program, International Research Center for Molecular Science in Tooth and Bone Diseases, Yushima 1-5-45,Bunkyo-ku, Tokyo 113-8549, Japan;

    Section of Nephrology, Endocrinology and Metabolism, Department of Internal Medicine, School of Medicine, Keio University, Shinanomachi 35, Shinjyuku-ku, Tokyo 160-8582, Japan;

    Department of Orthopedic Surgery, Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo 113-8549. Japan,Global Center of Excellence (GCOE) Program, International Research Center for Molecular Science in Tooth and Bone Diseases, Yushima 1-5-45,Bunkyo-ku, Tokyo 113-8549, Japan;

    Department of Orthopedic Surgery, Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo 113-8549. Japan;

    Department of Orthopedic Surgery, Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo 113-8549. Japan;

    Department of Orthopedic Surgery, Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo 113-8549. Japan;

    Department of Orthopedic Surgery, Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo 113-8549. Japan;

    Department of Physiology, School of Medicine, Keio University, Shinanomachi 35, Shinjyuku-ku, Tokyo 160-8582, Japan;

    Department of Orthopedic Surgery, Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo 113-8549. Japan,Global Center of Excellence (GCOE) Program, International Research Center for Molecular Science in Tooth and Bone Diseases, Yushima 1-5-45,Bunkyo-ku, Tokyo 113-8549, Japan;

    Section of Nephrology, Endocrinology and Metabolism, Department of Internal Medicine, School of Medicine, Keio University, Shinanomachi 35, Shinjyuku-ku, Tokyo 160-8582, Japan;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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