Ultrasensitive Electrical Biosensing of Proteins and DNA: Carbon-Nanotube Derived Amplification of the Recognition and Transduction Events

摘要

The detection of DNA and proteins is of central importance to the diagnosis and treatment of genetic diseases, to the detection of infectious agents, drug discovery, or warning against bio-warfare agents. Such biodetection commonly relies on hybridization or antigen-antibody (Ag-Ab) interactions, and requires proper attention to the achievement of ultrasensitive measurements. Electrochemical transducers are very attractive for such bioassays, owing to their high sensitivity, inherent simplicity and miniaturization, and low cost and power requirements.