Neighbor Effect on PPII Conformation in Alanine Peptides

摘要

Unfolded polypeptides have been demonstrated to have significant local structure while obeying overall random coil chain statistics.In particular the backbone polyproline II (PPII) (O = -75°,PSI = +145°) conformation is present in unfolded proteins and short peptides7 as well as coil libraries from the PDB.Temperature studies show that PPII conformation is in equilibrium with beta structure.