Biomimetic Synthesis of Antimalarial Naphthoquinones

Jeremiah P.Malerich; Thomas J.Maimone; Gregory I.Elliott; Dirk Trauner

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Biomimetic Synthesis of Antimalarial Naphthoquinones

机译：拟南芥抗萘醌的仿生合成

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摘要

The total synthesis of naphthoquinone natural products isolated from the Bignoniaceae plant family is described.Pinnatal,isopinnatal,sterekunthals A and B,pyranokunthones A and B,and anthrakunthone have been prepared along the lines of a biosynthetic proposal involving pericyclic reactions as key steps.The first case of catalysis in oxa 6pi electrocyclizations is reported.

机译：描述了从紫花菊科植物科中分离出来的萘醌天然产物的总合成。已按照涉及周环反应的生物合成方案的关键步骤，制备了品系，异品系，对映体A和B，吡喃酮A和B以及蒽酮。据报道，在oxa 6pi电环化中催化的第一例。

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《Journal of the American Chemical Society》 |2005年第17期|p.6276-6283|共8页
作者
Jeremiah P.Malerich; Thomas J.Maimone; Gregory I.Elliott; Dirk Trauner;
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作者单位

Contribution from the Department of Chemistry,University of California-Berkeley,Berkeley,California 94720-1460;

Contribution from the Department of Chemistry,University of California-Berkeley,Berkeley,California 94720-1460;

Contribution from the Department of Chemistry,University of California-Berkeley,Berkeley,California 94720-1460;

Contribution from the Department of Chemistry,University of California-Berkeley,Berkeley,California 94720-1460;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类化学;
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4. A New Method for the Biomimetic Synthesis of 2-Hydroxy-3-amino-1, 4-naphthoquinone [C] . Rui Liu, Hong Li, Wenyan Ma International Conference on Chemical Engineering and Advanced Materials . 2013

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5. Studies in synthetic organic chemistry: Part I. The synthesis of novel antimalarial artmeisinin dimers. Part II. Electronically stabilized versions of antimalarial acetal trioxanes. Part III. Novel analogs of natural hormone 1-alpha, 25-dihdroxyvitamin D3: Design, synthesis and biological evaluation of CYP24 inhibitors. Part IV. New silicon mediated ring expansions of N-sized 2-cycloalkenones into homoallylic N+3 sized lactones. [D] . Kalinda, Alvin Solomon. 2009

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6. Synthesis and Biological Evaluation of 14-Naphthoquinones and Quinoline-58-diones as Antimalarial and Schistosomicidal Agents [O] . Don Antoine Lanfranchi, Elena Cesar-Rodo, Benoît Bertrand, -1

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7. Biomimetic Synthesis of Antimalarial Naphthoquinones [O] . Jeremiah P. Malerich, Thomas J. Maimone, Gregory I. Elliott, 2007

机译：抗体基萘醌的仿生合成

Biomimetic Synthesis of Antimalarial Naphthoquinones

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