Palladium-Catalyzed Methylation of Aryl C-H Bond by Using Peroxides

摘要

Transition-metal-catalyzed activation of aryl C-H bonds followed by C-C bond formation provides a promising alternative to the standard coupling reactions using preformed organometallic reagents. In this area of research, various functional groups containing heteroatoms such as acetyl, acetoamino, oxazolyl, pyridyl, and imino groups can provide an anchor for either stoichiometric or catalytic ortho-metalation of aromatic rings, which leads to subsequent regioselective formation of C-C bonds for synthetic purposes. Ru and Rh complexes are the hors d'oeuvres of effective catalysts which have succeeded in performing carbo-functional-ization of aryl C-H bonds by reacting with olefins or aryl organometallic reagents.