Use of Local Alignment Tensors for the Determination of Relative Configurations in Organic Compounds

摘要

The determination of relative configurations in organic compounds by NMR spectroscopy always requires a simultaneous treatment of configuration and conformational interconversion, which is usually accomplished by using dihedral angles derived from J couplings distances from the nuclear Overhauser effect (NOE) or projection angles from cross correlated relaxation.rnThese conventional NMR parameters, however, do not always lead to unambiguous configurational assignments. It has recently been shown that residual dipolar couplings (RDCs) provide complementary information about configurational assignments, even in the case of moderate flexibility of the molecule.