A General Solution for Unstable Boronic Acids: Slow-Release Cross-Coupling from Air-Stable MIDA Boronates

摘要

Boronic acids can serve as excellent building blocks for the synthesis of a wide range of natural products, Pharmaceuticals, and materials. However, some of the potentially most useful boronic acids, including 2-heterocyclic, vinyl, and cyclopropyl derivatives, are inherently unstable, which can significantly limit their benchtop storage and/or efficient cross-coupling. Many important surrogates have been developed, including trifiuoroborate salts, trialkoxy or trihydroxyborate salts, diethanolamine adducts, sterically bulky boronic esters, and boroxines.