Stereoretentive cross-coupling of boronic acids

摘要

The present disclosure provides tri-orthoalkylphenyl phosphine catalysts of formula I; wherein A is CH2, C═O, or NR^A; R¹ is aryl, heteroaryl, isopropyl, tert-butyl, cycloalkyl, or heterocycloalkyl, wherein aryl, heteroaryl, cycloalkyl and heterocycloalkyl are optionally substituted; R² is H, (C₁-C₈)alkyl, (C₁-C₈)alkoxy, N(R^A)₂, or an electron withdrawing group; and each R^A is independently H or (C₁-C₈)alkyl; that are tuned electrically and sterically.