π-nucleophile Traps For Metallonitrene/alkyne Cascade Reactions: A Versatile Process For The Synthesis Of α-aminocyclopropanes And β-aminostyrenes

摘要

Inspired by the synthetic potential of a catalytic metallonitrene/ alkyne metathesis process, we recently disclosed a conceptually novel cascade reaction in which an electrophilic rhodium nitrenoid species was trapped by an alkyne, generating a new reactive intermediate that could react with tethered ethers in an ylide formation/migration sequence (Scheme 1). The development of this reaction established the viability of the metallonitrene/alkyne metathesis concept, but the nature of the reactive intermediate(s) remained unclear.