A Stable Lipid-lnduced Aggregate of α-Synuclein

摘要

α-Synuclein (αS) is a 140 residue protein constituting the major component of Lewy bodies found in Parkinson's disease, where it is aggregated into fibrils. Although the exact function of αS is yet to be determined, the interaction of αS with synaptic vesicles has been suggested to be important for its physiological role. While αS is natively unfolded in solution, upon binding to negatively charged membranes it adopts an amphipathic, α-helical structure involving residues 1-100.