Total Synthesis of L-Biopterin from L-Tartaric Acid via 5-Deoxy-L-arabinose

摘要

This work describes the synthesis of L-biopterin (1) starting from L-tartaric acid (3). This synthesis improves the preparation of lactone 4 by highly stereoselective addition of Grignard reagent on aldo ester 5. This excellent result prompted us to condense successfully several Grignard reagents on compound 5. These studies will be reported in due course.